The expressions of upregulated lncRNAs involved in CRC development and progression (CCAT1, MALAT1, and UCA1), sustaining proliferation (CCAT1, MALAT1, and UCA1), metastasis and invasion (CCAT1, H19, and HOTAIR), and clinical application (AFAP1-AS1, H19) were rarely altered in the solid tumor from SC and IP mice with high-dose Vc treatment. This evidence concerns the gene HOTAIR and colorectal carcinoma.