A very recent study also highlighted the ability of controlled exercise on a treadmill in mice to increase the striatal content of GDNF as well as normalize striatal levels of tyrosine hydroxylase and attenuate L-DOPA-induced dyskinesia (LID [173]), thus providing the first indication that the antidyskinetic effects of exercise may lead to an increase in striatal GDNF levels [174]. This evidence concerns the gene GDNF and Dyskinesia.