Exercise-induced BDNF release seems to carry out a crucial role in neuroplastic effects of rehabilitation interventions in humans with neurodegenerative disease, particularly with PD [183, 187–189], and it is believed that the physiologic mechanisms underlying exercise-induced BDNF changes in PD could include long-term potentiation (LTP) and long-term depression (LTD) mechanisms [190, 191]. This evidence concerns the gene BDNF and neurodegenerative disease.