F3 and thrombotic disease: In this situation, the participation ofTF is a hallmark event which is responsible for procoagulant effects that lead tohemorrhagic and thrombotic disorders [14].Tissue factor is a transmembrane glycoprotein that forms the extrinsic tenasecomplex with FVIIa, and is expressed mostly by endothelial cells and monocytesthrough different stimuli such as pathogenic agents and their isolated components,such as LPS, as well as inflammatory mediators [37].