LPL and metabolic dysfunction-associated steatotic liver disease: Additionally, lipoprotein lipase (LPL) also has well-characterized role in the pathophysiology of NAFLD: lipoprotein metabolism is the central pathway for the hepatocellular lipid homeostasis22,23; more recently, the up-regulation of LPL in hepatic stellate cells has also been demonstrated to exacerbate liver fibrosis in non-alcoholic steatohepatitis (NASH)24, which can be considered as a subtype of NAFLD.