Genes from the constructed protein-interaction network provide a first snapshot of a comprehensive image: IFI16 controls the interferon response to the virus31, LIMA1 mediating the interaction between Cadherins (CDH1, CDH13) and Actin in the context of adherens junctions potentially playing a role in virus infection, CALM1 inhibits shedding of the ectodomain of the virus receptor ACE236. This evidence concerns the gene CALM1 and viral infectious disease.