The down-regulated signaling pathways included thyroid hormone synthesis, cocaine addiction, metabolism of xenobiotics by cytochrome P450, legionellosis, glycerolipid metabolism, chemical carcinogenesis, amphetamine addiction, acute myeloid leukemia, adherens junction, Salmonella infection, protein digestion and absorption, and hematopoietic cell lineage (Tables 9 and 10 and Fig. 6). Here, TG is linked to cocaine dependence.