Zhang, et al. reported six macrophage clusters identified in hepatocellular carcinoma, and found that a macrophage cluster (M4-C1-THBS1 in their analysis) was enriched for signatures of MDSC, similar to ours MDSC-C1-C1QC and MDSC-C2-APOE; they also found another cluster M4-C2-C1QA, co-existed with M1 and M2 signatures20. The gene discussed is THBS1; the disease is hepatocellular carcinoma.