After confirming the knockdown of ACLY in macrophages, myeloid dendritic cells, and neutrophils from those mice (hereafter referred to as AclyM-KO, Supplementary Fig. 1d, e), we transplanted lethally irradiated atherosclerosis-susceptible Ldlr-deficient mice with bone marrow from either AclyM-KO mice or Cre-negative Aclyfl/fl littermate control mice. The gene discussed is LDLR; the disease is atherosclerosis.