LMNA and progeroid syndrome: To evaluate whether bivalent genes are especially affected in progeria, we performed a Fisher test: we found 76 bivalent out of 257 differentially expressed genes in HGPS (Fisher test p-value < 2.2e−16); or 39 bivalent out of 144 upregulated genes in HGPS (Fisher test p-value 4.32e−12).