INS and Hypoglycemia: Interestingly, contrary to in vitro neurophysiological responses to glucose8, insulin-induced hypoglycemia and 2-deoxyglucose-mediated glucopenia each induce c-fos mRNA expression in ARC POMC neurons in vivo13, suggesting that ARC POMC neuronal activity increases in response to hypoglycemia, possibly due to altered synaptic strength at ARC POMC neuronal synapses.