Moreover, compared to TAMs from WT tumor-bearing mice, those from Ubr5−/− tumor-bearing mice exhibited higher levels of M1 macrophage markers (e.g., il12a, Ccr2) and lower levels of M2 markers (e.g., Cx3cr1, il10) (Fig. 4b and Supplementary Fig. 6b). The gene discussed is CX3CR1; the disease is neoplasm.