UBR5 and neoplasm: Moreover, compared to TAMs from WT tumor-bearing mice, those from Ubr5−/− tumor-bearing mice exhibited higher levels of M1 macrophage markers (e.g., il12a, Ccr2) and lower levels of M2 markers (e.g., Cx3cr1, il10) (Fig. 4b and Supplementary Fig. 6b).