UBR5 and neoplasm: Nonetheless, LC depleted peritoneal TAMs in the ID8/GFP group to a level even lower than that in ID8/Ubr5−/− group (Fig. 3e and Supplementary Fig. 5i–k), but ID8/GFP bearing mice lacking TAMs still demonstrated a higher tumor burden (Fig. 3f) with more proliferative cells (Fig. 3g and Supplementary Fig. 5j), spheroid accumulation (Fig. 3h), and shorter survival (Fig. 3i) than the ID8/Ubr5−/− group without LC treatment.