TP53 and cancer: However, in a HGSC cohort30, we identified a close association between UBR5 alterations and TP53 mutations, i.e., cancers with UBR5 gene alterations, predominantly amplification and gains, harbored frequent TP53 mutations, whereas those in the diploid state (without UBR5 alterations) were mostly without TP53 mutations (Fig. 5k), suggesting a possible regulatory relationship between UBR5 alterations and TP53 mutations.