At 30 days post injection, we observed ~two times more ID8/Ubr5−/− tumor cells in the lungs compared with control tumor cells (Fig. 1c), but there were far fewer pulmonary and liver metastatic nodules in mice bearing ID8/Ubr5−/− at 60 days post injection (Fig. 1d and Supplementary Fig. 2g, h). The gene discussed is UBR5; the disease is neoplasm.