MITF and melanoma: To control the survival and invasiveness of melanoma, MITF activates the antiapoptotic gene BCL2 and the cell cycle regulators, CDK2 and CDKN1A [18–20], whereas MITF suppresses invadopodia formation by upregulating GMPR and DIAPH1 expression, which influences the activities of small GTPases and cytoskeleton remodeling [13, 21].