Importantly, HIV-1 infection or Vpr production was also correlated with the upregulation of the Sur1-Trpm4 channel (Fig. 1 to 4), and a Sur1 inhibitor glibenclamide inhibited Vpr-induced apoptosis in a concentration-dependent manner in SNB19 cells (Fig. 5). Here, ABCC8 is linked to HIV-1 infection.