Targeted mutational analysis of patients with de novo and secondary AML revealed that mutations in SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, or STAG2 were highly specific for secondary AML and occurred early in leukemogenesis [101]. The gene discussed is SF3B1; the disease is acute myeloid leukemia.