Lens hydration was the most prevailing hypothesis that explained the change of lens dimension in participants with DM [10, 11], which was strongly supported by the generalized growth of lens in DM found by Wiember et al. [12] With sorbitol dehydrogenase, excessive glucose absorbed by lens due to hyperglycemia is converted into sorbitol and fructose (polyol pathway), which has poorer permeability through lens membrane. Here, SORD is linked to diabetes mellitus.