They may be important in the mitigation of COVID-19 [5, 9, 10], acting through the endoplasmic reticulum (ER) [11–13] or ACE-Angiotensin-II-AT1R axis (AT1R) pathway [3, 5] and leading to insulin resistance (IR), endothelial damage, lung injury and cytokine storm. The gene discussed is AGT; the disease is COVID-19.