CD274 and neoplasm: As expected, cytotoxic effect was not observed in the mice bearing NCI-H292 cells no matter treated with the first-generation HER2 CAR-T cells or dual-targeted CAR-T cells (Fig. 6f), However, the dual-targeted CAR-T cells could exert significantly suppress on HER2+PD-L1+ tumor xenografts (Fig. 6g), suggesting that dual-targeted CAR-T cells could selectively kill PD-L1+ tumor cells but not the normal tissues.