A recent scRNA-seq study conducted in human intrahepatic cholangiocarcinoma (ICC) found five CAF subpopulations: vascular CAFs (vCAFs) defined by MCAM expressing high level of IL-6, matrix CAFs (mCAFs) defined by POSTN, iCAFs defined by FBLN1, apCAFs defined by CD74 and EMT-like CAFs defined by KRT19 [59]. This evidence concerns the gene IL6 and intrahepatic cholangiocarcinoma.