Moreover, tumor orchestrates an immune inhibitory microenvironment, containing regulatory immune cells such as regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs), which also compromise the effector function of CAR T cells through inhibitory ligands (e.g. PD-L1) and/or cytokines (e.g., IL-10, TGF-β and arginase) [105, 106]. This evidence concerns the gene CD274 and neoplasm.