TGFB1 and neoplasm: In recent researches, it was reported that tumor-associated macrophages (TAMs) could secret TGFβ1 to promote LCSC properties by inducing EMT [29], and tumor-associated neutrophils (TANs) could secret TGFβ2 and BMP2, which induce miR-301b-3p and enhance stem cell characteristics in HCC [30].