A previous study investigated the effect of neoadjuvant chemotherapy on LDLR expression in locally advanced breast cancer using a polyclonal antibody, querying that the overexpression of LDLR is caused by elevated lipid-dependent membrane synthesis in highly proliferative cells, but the results showed no effect of chemotherapy and the subsequent reduction of mitosis on LDLR expression [68]. Here, LDLR is linked to breast carcinoma.