Mechanistically, HBVx can promote liver carcinogenesis through CREB-miR-3188 and ZHX2-Notch signaling pathway [57], promote HCC cell growth by activating CREB-YAP axis [58], and promote the invasion and metastasis of HBV-related HCC by up-regulating FOXM1 expression through Erk-CREB pathway [59]. Here, ZHX2 is linked to hepatocellular carcinoma.