P53, which has long been known as a regulator of apoptosis in cancers including breast cancer by controlling expression of apoptosis-associated genes such as BCL2-associated X protein (BAX), apoptotic peptidase activating factor 1 (APAF-1), p53-upregulated modulator of apoptosis (PUMA), p53-regulated apoptosis-inducing protein 1 (p53AIP1), p53-induced death domain protein 1 (PIDD) and Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (NOXA) [124, 125], has been shown to participate in ferroptosis in breast cancer as mentioned above. This evidence concerns the gene APAF1 and breast cancer.