TP53 and breast cancer: In 2020, Dinarvand et al. compared 55 pairs of fresh samples of BC and adjacent non-cancerous tissue, and they reported that ACSL4 had higher expression in breast cancer tissues than adjacent normal tissue, and its expression level was negatively correlated with Ki-67 and age and positively with the mutant p53 level; however, it was not associated with the expression of ER, PR or HER2 [285].