Additionally, starved breast cancer cells in glucose-, amino acid- and serum-free conditions can also induce apoptosis, autophagy and necroptosis, while the transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1) inhibits cell death by stabilizing the X-linked inhibitor of apoptosis protein (XIAP) and decreasing ROS production [123]. The gene discussed is XIAP; the disease is breast cancer.