In 2017, Caitlin et al. showed that extracellular matrix (ECM) detachment is a physiologic trigger of ferroptosis in breast cancer cells due to suppression of GPX4, and α6β4 integrin can help cells evade this process by protecting against changes in membrane lipids, activating Src and STAT3 and suppressing expression of ACSL4 [86]. The gene discussed is ACSL4; the disease is breast carcinoma.