PNPLA2 and breast carcinoma: A similar phenomenon was observed in a study by Panzilius et al., who found that ﻿low cell density sensitizes﻿ primary mammary epithelial and breast cancer cells to induction of ferroptosis by accumulating neutral triacylglycerides (TAG) enriched with PUFAs and triggering liberation of fatty acids from lipid droplets by adipose triglyceride lipase (ATGL) to fuel β-oxidation, whereas a high cell density confers resistance [88, 89].