RHOA and angioimmunoblastic T-cell lymphoma: Interestingly, gene set enrichment analysis of PTCL-NOS and AITL cases with the mutant G17A compared to those with wild type RHOA revealed that there is a relationship between RHOA and Rac1 in which a high level of Rac activity leads to activation of multiple downstream signals, including the NFκB, p38 mitogen-activated protein kinase, and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways [21].