The PTCL-GATA3 subgroup, accounting for 33% of PTCL-NOS, has an enrichment of MYC and cytotoxic gene with poorer outcome while the PTCL-TBX21 subgroup that constitutes 49% of PTCL-NOS, has a tumor microenvironment gene signature and is associated with a favorable outcome. This evidence concerns the gene MYC and neoplasm.