In the study by Herder et al. for instance, the high concentrations of C-reactive protein and IL6, that were associated with cardiovascular autonomic dysfunction in the unadjusted model, lost statistical significance after adjusting for anthropometric and metabolic variables, showing that the baseline conditions of individuals with T2D by themselves are already associated with subclinical inflammation [10]. The gene discussed is IL6; the disease is type 2 diabetes mellitus.