For TNF and IL10, Dunn's post-test did not show differences between groups while concentration of LTB4 was higher in those presenting incipient CAN (69.7 ± 16.6 pg mL−1) and definitive CAN (71.5 ± 15.7 pg mL−1) versus those without CAN (57.0 ± 13.9 pg mL−1). Here, TNF is linked to Crouzon syndrome-acanthosis nigricans syndrome.