The term “Severe Asthma with Fungal Sensitisation” (SAFS) was introduced by Denning et al. in 2006, to describe those patients who have persistent severe asthma (despite standard treatment) and evidence of fungal sensitisation, as defined by positive SPT, or fungus or fungal antigen-specific IgE, and do not meet the criteria for ABPA [3]. This evidence concerns the gene IGHE and asthma.