Fungal specific IgE sensitisation to A. fumigatus has been reported in a population of asthmatics with fixed airflow obstruction and radiological abnormalities [7] which suggests that the sensitisation to thermotolerant filamentous fungi is the major risk factor for the development for lung damage in asthma irrespective of whether the criteria for ABPA are present [39, 40]. The gene discussed is IGHE; the disease is asthma.