SLC40A1 and atherosclerosis: The data from both Hamp−/−/Ldlr−/− [16] and Apoe−/−Fpn1LysM/LysM (this work) models reciprocally demonstrated that low levels of iron in macrophages induced by upregulated Fpn1 protected against atherosclerosis and that high levels of iron in macrophages induced by Fpn1 depletion accelerated the progression of atherosclerosis.