We also showed that intracellular TAGE production reduced amyloid β levels and increased total tau and p-tauT181 levels in the culture media and the intracellular levels of AD biomarkers (i.e., total tau, p-tauT181, VEGF, and TGF-β) in human neuroblastoma SH-SY5Y cells [32]. The gene discussed is MAPT; the disease is neuroblastoma.