PGR and endometrium adenocarcinoma: To further understand the molecular mechanism(s) by which the P4-PR signaling pathway regulates Pla2g10 expression at transcriptional levels, a series of luciferase assays with a proximal promoter region of Pla2g10 gene containing putative PR response elements (PREs) was performed in Ishikawa cells, human endometrial adenocarcinoma cells.