The expression of SIRT1 in the EPO-BMSCs + AKI-KHS group was significantly increased compared with that in the BMSCs + AKI-KHS group (p < 0.05), and the expression of p53 was significantly higher in the BMSCs + AKI-KHS group than in the EPO-BMSCs + AKI-KHS group (p < 0.05). The gene discussed is TP53; the disease is acute kidney injury.