The median levels of AFP and PIVKA-II in HBV-related HCC patients without vascular invasion were 15 (IQR 3.4 ~ 69) and 174.71 (IQR 46.76 ~ 1156.6), while their concentrations of patients with vascular invasion were 45 (IQR 6.37 ~ 1039.2) and 549.3 (IQR 65.13 ~ 7805.3) respectively. Here, AFP is linked to hepatocellular carcinoma.