GCKR and type 2 diabetes mellitus: The mutation or gene variants of GCKR was reported to be associated with several clinical manifestation, such as T2DM [36], nonalcoholic fatty liver disease (NAFLD) [37], familial combined hyperlipidemia (FCHL) [38], coronary artery disease, ischemic stroke [39], gout [40] and chronic kidney disease [41].