Compared with the control group, serum levels of BNP, NT-proBNP, LDH, CK-MB, and AST in the DOX group were significantly increased (P < 0.01) while serum levels of ATP, ATPase, NAD, and NADH were decreased in the DOX group (P < 0.01), which indicated the damage of heart function and energy metabolism disorder in DOX group. Here, NPPB is linked to Disorder of energy metabolism.