H-C-T network and PPI network analysis showed that the active components of ephedra-bitter almond were anti-COVID-19 mainly by regulating PTGS2, HSP90AA1, AR, PPARG, NCOA2, RELA, AKT1, BCL2, TNF, JUN, CASP3, RXRA and MAPK1. This evidence concerns the gene MAPK1 and COVID-19.