Regarding AIHA secondary to CLL, abnormalities in the regulatory mechanisms of the immune response were observed, including down-regulation of miRNAs [69], the presence of autoreactive polyclonal B cells (mainly IgG class) and neoplastic monoclonal B lymphocytes (mainly IgM class) [64], induction of autoreactive Th cells through B cell activator (BAFF) and a proliferation inducing ligand (APRIL), formation of nonfunctional Tregs [70], reduction of Toll-like receptors (TLR4), a lower expression of TLR2, and an increases of TLR7, TLR9, and TLR10 [71]. This evidence concerns the gene TNFSF13 and autoimmune hemolytic anemia.