CDKN2A and squamous cell intraepithelial neoplasia: Studies have shown that detection of Ki-67 (MIB-1) nuclear biomarker and p16ink4a cytoplasmic biomarker in cervical epithelial cells is useful in detection of Low-grade squamous intraepithelial lesion (LSIL) [31], and can help to predict the prognosis of which cases of Atypical Squamous Cells of Undetermined Significance (ASCUS) and LSIL will progress to High-grade squamous intraepithelial lesion (HSIL), and invasive cancer.