REN and obesity due to melanocortin 4 receptor deficiency: Perhaps of relevance to the increased risk associated with obesity is that high ACE2 expression has been found in both visceral and subcutaneous adipose tissue; this is important as adipose tissue in obesity is well known to secrete higher levels of angiotensin 2, an inflammatory component of the renin-angiotensin aldosterone system (RAAS), which is key in driving many of the pathological complications associated with this condition [53].