NLRP3 and arthritic joint disease: Moreover, this drug reduced the swelling of the paw in model rats with arthritis; inhibited the proliferation and transfer of synovial cells and release of inflammatory cytokines; decreased the protein expression of inflammasome NLRP3, caspase-1, and IL-1β; inhibited inflammatory cell infiltration and angiogenesis; promoted apoptosis; reduced serum inflammatory factors IL-1β and TNF-α levels; and significantly inhibited the inflammatory reaction.