AREG and colorectal carcinoma: We found that overexpression of RASSF1 abolished the effect of SKP1 on the expression of YAP target genes (CTGF and AREG) (Fig. 7b), sphere-forming capacity (Fig. 7c), the frequency of sphere-forming cells (Fig. 7d), migration capacity (Fig. 7e), and the expression of cancer stem cell markers (SOX2, ALDH1, CD44 and CD133) (Fig. 7f, left) and EMT markers (SNAI2, Vimentin and E-cadherin) (Fig. 7f, right) in CRC cells, which confirmed that RASSF1 is the target of SKP1 inhibiting Hippo/YAP signaling and CRC stemness.