One cluster of proteins more abundant in active TB compared to the other groups (α-1-acid glycoprotein 1 (ORM1), C-reactive protein (CRP), sialic acid-binding Ig-like lectin16 (SIGLGC16), and serum amyloid A-1 protein (SAA1) is enriched in proteins functionally associated with the acute phase (inflammatory) response. Here, ORM1 is linked to tuberculosis.