Univariate analysis indicated that tumor size (P < 0.001), depth of invasion (P < 0.001), lymph node metastasis (P < 0.001), TNM stage (P < 0.001), vascular invasion (P = 0.003), and FSTL1 expression (P < 0.001) were significantly correlated with OS of GC patients. The gene discussed is FSTL1; the disease is gastric cancer.