MMP2 and cancer: For instance, SLC39A6 can enhance the aggressive phenotype by inducing human pancreatic cancer cell epithelial-mesenchymal transition [9]; SLC39A7 silencing significantly up-regulates expression of Bax and E-cadherin, down-regulates expression of Bcl-2 and MMP2, and inhibits cell proliferation, migration and invasion of cervical cancer [10]; SLC39A4 increases lung cancer cell epithelial-mesenchymal transition and inhibits the sensitivity of cisplatin to cancer cells, promoting lung cancer cell proliferation and invasion [11].