The activation of multiple signaling pathways in tumor cells that promote cell proliferation and survival, such as the activation of B-cell receptor (BCR) and its downstream pathway signaling molecules [45, 46] and the activation of the ERK pathway caused by the activation of extracellular receptors [36], can induce the upregulation of BCL2 family anti-apoptotic proteins, which is one of the mechanisms of venetoclax resistance caused by the microenvironment. The gene discussed is BCL2; the disease is neoplasm.