Additionally, Schagdarsurengin et al. investigated the role of RASSF1A during liver carcinogenesis in vitro, they analysed the methylation status of the RASSF1A promoter in HBV-positive human hepatocellular carcinoma cell line (Hep3B) and found RASSF1A promoter CpG island was hypermethylated [20]. The gene discussed is RASSF1; the disease is hepatocellular carcinoma.