Meanwhile, the time-dependent AUC values concerning RASSF1A gene promoter hypermethylation in the prediction of the OS of HCC patients at 1, 2, 3 and 5 years were 0.61, 0.69, 0.63 and 0.73, separately (Fig. 5d). Here, RASSF1 is linked to hepatocellular carcinoma.