We also revealed that TXNRD1 could positively regulate cylclinB1 and adhesion molecule ICAM1 and VCAM1 to promote the proliferation and adhesion abilities of ESCC cells and negatively regulate pro-apoptotic proteins Cleaved PARP, Bax and Cleaved Caspase-3. This evidence concerns the gene CASP3 and esophageal squamous cell carcinoma.