CASP3 and esophageal squamous cell carcinoma: After we designed caspase 3 activity assay to further explore the effect of circ0120816 on cell apoptosis of ESCC cells, we found that si-circ0120816 facilitated cell apoptosis by about five-fold and OE–circ0120816 and miR-1305 inhibitor restrained cell apoptosis by about 50% and 60%.