For example, in neuroblastoma, bioinformatics analysis of a large number of human neuroblastoma samples showed that genes associated with polyamine biosynthesis, including ODC1, AMD1, ARG1, AZIN1, DHPS, EIF5A, MAT1B, SMS, SMOX, and SRM, were upregulated in MYCN-amplified/upregulated neuroblastoma. The gene discussed is SMS; the disease is neuroblastoma.