Based on the results observed during this study, we conclude that YFJP attenuated HCC progression through mediating HCC-related genes (including TP53, EGFR, EGF, CCND1, JUN, AKT1, IL6, MAPK1, VEGFA, ESR1, CASP3, and PTGS2). Here, PTGS2 is linked to hepatocellular carcinoma.