Putative targets for YFJP treatment of HCC were screened, from which 12 key targets (TP53, EGFR, EGF, CCND1, JUN, AKT1, IL6, MAPK1, VEGFA, ESR1, CASP3, and PTGS2) were obtained (Fig. 7a). The gene discussed is ESR1; the disease is hepatocellular carcinoma.