Proviral insertion in murine lymphomas 2, a protein kinase acting as an oncogene, has been shown to phosphorylate PKM2 at Thr454, which facilitates the transcriptional co-activation of HIF-1α and β-catenin transcription factors to promote non-glycolytic nuclear function of PKM2 and tumor growth [83]. This evidence concerns the gene WEE1 and neoplasm.