PKM2 phosphorylates mTORC1 inhibitor AKT1 substrate 1 (AKT1S1) at Ser202/203, and PKM2-induced AKT1S1 phosphorylation promotes PKM2 binding to 14-3-3, activating mTORC1 signaling and accelerating oncogenic growth in cancer cells [77]. This evidence concerns the gene AKT1S1 and cancer.