KLK3 and posterior cortical atrophy: Here it was shown that a combination of plasma protein biomarkers (PSA, fPSA, hexokinase 2 (hK2), microeminoprotein beta (MSMB), and macrophage inhibitory cytokine 1 (MIC1)), genetic polymorphisms and clinical variables (age, family history, previous prostate biopsy and prostate exam) performed significantly better than PSA alone for detection of PCa.