IGF1R and metabolic disease: For instance, one study investigated the effects of insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF-1R) on outcomes of metabolic disease in chow-fed mice by generating adipocyte-specific inducible knockout (KO) models of one (IRKO or IGF-1RKO) or both of these receptors (double KO; DKO [122]).